Utilizing solitary-molecule optical and AFM imaging and drive-spectroscopy methods, we search for to unravel the mechanistic aspects of the construction and dynamics of chromosomes. Our exploration pursuits contain:
Our team studies bacterial mobile division and it is aiming to represent a ‘base up biology’ in synthetic cells which will autonomously divide. Our primary fascination lies in mobile division, chromatin structure, and spatial Management.
As being a human being, I provide the biblical assignment to explore and use every little thing in development for the good thing about my neighbour. I do not expertise any conflict involving religion and science. Quite the opposite, my religion stimulates me to complete science, for being open up-minded on the globe.’
Non-equilibrium folding of person DNA molecules recaptured as much as 1000 times in a solid point out nanopore
We develop issue-of-treatment diagnostics check of neglected tropical illnesses in just source-restricted settings, dependant on Crspr/Cas9 detecting of pathogen’s DNA in human body fluids.
SMC complexes can pass physical roadblocks bigger than their ring dimension, indicating a nontopological mechanism for DNA loop extrusion
‘Initially we checked out biological programs with a Bodily perspective and acted on The idea of your resources we realized. It took a few years in advance of we started Doing work more on the large Organic issues. I then started to simply call it nanobiology, a term that did not exist at enough time.
Circulation-pushed rotary motors including windmills and h2o wheels drive useful processes in human Culture. Whilst examples of these rotary motors also function prominently in cell biology, their artificial construction at the nanoscale has remained hard. Listed here we demonstrate stream-driven rotary motion of the self-structured DNA nanostructure that's docked on to a nanopore in a skinny solid-condition membrane. An elastic DNA bundle self-assembles right into a chiral conformation on phoretic docking onto the sound-point out nanopore, and subsequently shows a ceesdekker sustained unidirectional rotary motion of up to 20 rev s−1.
Understanding basic processes regulating the spatial and dynamic organisation from the DNA in Reside cells.
Resolving the action measurement in condensin-driven DNA loop extrusion identifies ATP binding as the action-creating method
An built-in microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes
Several new phenomena were being identified, and he and his investigate group recognized a number one place With this area of exploration. Dekker and his research group learned new physics of nanotubes in addition to explored the feasibility of molecular electronics. In 1998, they ended up the main to construct a transistor based upon a single nanotube molecule.
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Ultimately, I will briefly sketch a number of our Strategies to discover the developing of synthetic cells, specifically our first ways to determine artificial cell division.